Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study

Autor: Grønbæk, Jonathan Kjær, Wibroe, Morten, Toescu, Sebastian, Frič, Radek, Thomsen, Birthe Lykke, Møller, Lisbeth Nørgaard, Grillner, Pernilla, Gustavsson, Bengt, Mallucci, Conor, Aquilina, Kristian, Fellows, Greg Adam, Molinari, Emanuela, Hjort, Magnus Aasved, Westerholm-Ormio, Mia, Kiudeliene, Rosita, Mudra, Katalin, Hauser, Peter, van Baarsen, Kirsten, Hoving, Eelco, Zipfel, Julian, Nysom, Karsten, Schmiegelow, Kjeld, Sehested, Astrid, Juhler, Marianne, Mathiasen, René, Grønbæk, Jonathan Kjær, Wibroe, Morten, Toescu, Sebastian, Frič, Radek, Møller, Lisbeth Nørgaard, Grillner, Pernilla, Gustavsson, Bengt, Mallucci, Conor, Aquilina, Kristian, Molinari, Emanuela, Hjort, Magnus Aasved, Westerholm-Ormio, Mia, Kiudeliene, Rosita, Mudra, Katalin, Hauser, Peter, van Baarsen, Kirsten, Hoving, Eelco, Zipfel, Julian, Nysom, Karsten, Schmiegelow, Kjeld, Sehested, Astrid, Juhler, Marianne, Mathiasen, René, Kjærsgaard, Mimi, Bøgeskov, Lars, Skjøth-Rasmussen, Jane, Hauerberg Tamm, John, Poulsgaard, Lars, Gudrunardottir, Thora, Grønbæk, Sylvester Kløcker, Blichfeldt, Alberte, Raben-Levetzau, Felix Nicolai, Thude Callesen, Michael, Rathe, Mathias, Klokker, Rikke Bassø, von Oettingen, Gorm, Mikkelsen, Torben, Henriksen, Louise Tram, Cortnum, Søren, Tofting-Olesen, Kamilla, Karppinen, Atte, Solem, Kristin, Torsvik, Ingrid Kristin, Mosand, Ann-Karin, Simonsen, Line Rapp, Ehrstedt, Christoffer, Kristiansen, Ingela, Fritzson, Karin, Balestrand Haga, Line, Fagerholt, Hege Kristine, Stømqvist Blixt, Helene, Sundgren, Hanna, Håkansson, Yvonne, Castor, Charlotte, Nyman, Per, Wretman, Anne, Nilsson, Pelle, Bjørklund, Ann-Christin, Sabel, Magnus, Haij, Inga-Lill, Nilsson, Frans, Olausson, Hanna, Cummings, Claire, Flemming, Jade, Afolabi, Deborah, Phipps, Kim, Kamaly, Ian, Williams, Sharon, Jeelani, Noor-ul-Owase, McArthur, Donald, Wiles, Elisabeth, Walker, David, Cooper, Rebecca, Fellows, Greg, Hoole, Lizzy, Slater, Kirsty, Kandasamy, Jothy, McAndrew, Rachel, McLaughlin, Katie, Schumann, Martin, Avula, Shivaram, Pizer, Barry, Rutkauskiene, Giedre, Matukevicius, Algimantas, van den Abbeele, Leonie, Markia, Balázs, Pálmafy, Beatrix, Clausen, Niels, Ottosen Møller, Karen Margrethe, Thomassen, Harald, Cappelen, Johan, Stensvold, Einar, Devennay, Irene, Lønnqvist, Tuula, Nordfors, Kristiina, Lähteenmäki, Päivi
Zdroj: The Lancet Child & Adolescent Health; November 2021, Vol. 5 Issue: 11 p814-824, 11p
Abstrakt: Brain tumours are the most common solid tumours in childhood. Half of these tumours occur in the posterior fossa, where surgical removal is complicated by the risk of cerebellar mutism syndrome, of which postoperative speech impairment (POSI) is a cardinal symptom, in up to 25% of patients. The surgical approach to midline tumours, mostly undertaken by transvermian or telovelar routes, has been proposed to influence the risk of POSI. We aimed to investigate the risk of developing POSI, the time course of its resolution, and its association with surgical approach and other clinical factors.
Databáze: Supplemental Index