| Autor: |
Alexandrova, N, Niklinski, J, Bliskovsky, V, Otterson, G A, Blake, M, Kaye, F J, Zajac-Kaye, M |
| Zdroj: |
Molecular and Cellular Biology; September 1995, Vol. 15 Issue: 9 p5188-5195, 8p |
| Abstrakt: |
The polymerization of alpha- and beta-tubulin into microtubules results in a complex network of microfibrils that have important structural and functional roles in all eukaryotic cells. In addition, microtubules can interact with a diverse family of polypeptides which are believed to directly promote the assembly of microtubules and to modulate their functional activity. We have demonstrated that the c-Myc oncoprotein interacts in vivo and in vitro with alpha-tubulin and with polymerized microtubules and have defined the binding site to the N-terminal region within the transactivation domain of c-Myc. In addition, we have shown that c-Myc colocalizes with microtubules and remains tightly bound to the microtubule network after detergent extraction of intact cells. These findings suggest a potential role for Myc-tubulin interaction in vivo. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
