| Autor: |
Day, Jeremy N., Hoang, Thu N., Duong, Anh V., Hong, Chau T. T., Diep, Pham T., Campbell, James I., Sieu, Tran P. M., Hien, Tran T., Bui, Tien, Boni, Maciej F., Lalloo, David G., Carter, Dee, Baker, Stephen, Farrar, Jeremy J. |
| Zdroj: |
Journal of Clinical Microbiology; February 2011, Vol. 49 Issue: 2 p658-664, 7p |
| Abstrakt: |
ABSTRACTCryptococcal disease most commonly occurs in patients with an underlying immune deficit, most commonly HIV infection, and is due to Cryptococcus neoformansvar. grubii. Occasionally disease due to this variety occurs in apparently immunocompetent patients. The relationship between strains infecting immunosuppressed and immunocompetent patients is not clear. Amplified fragment length polymorphism (AFLP) analysis was used to characterize the relationship between strains infecting HIV-infected and uninfected patients. Isolates from 51 HIV-uninfected patients and 100 HIV-infected patients with cryptococcal meningitis were compared. C. neoformansvar. grubiiVNI was responsible for infections in 73% of HIV-uninfected and 100% of HIV-infected patients. AFLP analysis defined two distinct clusters, VNI? and VNId. The majority (84%) of isolates from HIV-uninfected patients were VNI?, compared with only 38% of isolates from HIV-infected patients (odds ratio, 8.30; 95% confidence interval [CI], 3.04 to 26.6; P< 0.0001). In HIV-uninfected patients, underlying disease was less frequent in those with VNI? infections. Two clusters of C. neoformansvar. grubiiVN1 are responsible for the majority of cases of cryptococcal meningitis in Vietnam. The distribution of these clusters differs according to the immune status of the host. |
| Databáze: |
Supplemental Index |
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