Mycobacterium tuberculosisin Ontario, Canada: Insights from IS6110Restriction Fragment Length Polymorphism and Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Genotyping

Autor: Alexander, David C., Guthrie, Jennifer L., Pyskir, Daria, Maki, Anne, Kurepina, Natalia, Kreiswirth, Barry N., Chedore, Pamela, Drews, Steven J., Jamieson, Frances
Zdroj: Journal of Clinical Microbiology; August 2009, Vol. 47 Issue: 8 p2651-2654, 4p
Abstrakt: ABSTRACTA collection of 1,308 clinical Mycobacterium tuberculosisisolates from Ontario, Canada, was genotyped by IS6110restriction fragment length polymorphism (RFLP) and mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) analysis. RFLP or >12 MIRU-VNTR loci were necessary for resolution of Indo-Oceanic strains. The low clustering rate and high strain diversity indicate that, in Ontario, most tuberculosis results from reactivation of latent infections.
Databáze: Supplemental Index