| Autor: |
Bertrand, Sophie, Weill, Franc¸ois-Xavier, Cloeckaert, Axel, Vrints, Martine, Mairiaux, Eric, Praud, Karine, Dierick, Katlijne, Wildemauve, Christa, Godard, Claudine, Butaye, Patrick, Imberechts, Hein, Grimont, Patrick A. D., Collard, Jean-Marc |
| Zdroj: |
Journal of Clinical Microbiology; August 2006, Vol. 44 Issue: 8 p2897-2903, 7p |
| Abstrakt: |
ABSTRACTAntibiotic treatment is not required in cases of Salmonella entericagastroenteritis but is essential in cases of enteric fever or invasive salmonellosis or in immunocompromised patients. Although fluoroquinolones and extended-spectrum cephalosporins are the drugs of choice to treat invasive Salmonella, resistance to these antibiotics is increasing worldwide. During the period 2000 to 2003, 90 Salmonella entericaserovar Virchow poultry and poultry product isolates and 11 serovar Virchow human isolates were found to produce an extended-spectrum ß-lactamase, CTX-M-2, concomitantly with a TEM-1 ß-lactamase. The blaCTX-M-2gene was located on a large conjugative plasmid (>100 kb). Pulsed-field gel electrophoresis indicated a clonal relationship between the poultry and human isolates. All these isolates displayed additional resistance to trimethoprim-sulfamethoxazole and tetracycline as well as a reduced susceptibility to ciprofloxacin (MICs of between 0.5 and 1 µg/ml). CTX-M-2-producing Salmonellawith a reduced susceptibility to fluoroquinolones constitutes a major concern, since such strains could disseminate on a large scale and jeopardize classical antibiotic therapy in immunocompromised patients. |
| Databáze: |
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