| Autor: |
Sarvikivi, Emmi, Lyytika¨inen, Outi, Soll, David R., Pujol, Claude, Pfaller, Michael A., Richardson, Malcolm, Koukila-Ka¨hko¨la¨, Pirkko, Luukkainen, Pa¨ivi, Saxe´n, Harri |
| Zdroj: |
Journal of Clinical Microbiology; June 2005, Vol. 43 Issue: 6 p2729-2735, 7p |
| Abstrakt: |
ABSTRACTCandida parapsilosisis an increasing cause of bloodstream infections (BSIs) in neonatal intensive care units (NICUs). It has been a persistent problem in the NICU of Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland, since 1987. Fluconazole prophylaxis has been used to control the problem. The number of new infections has, however, increased markedly since September 2000. We assessed fluconazole consumption and occurrence of all Candidaspecies in the NICU from 1991 to 2002. C. parapsilosisbloodstream isolates obtained in the NICU from 1990 to 2002 (n= 26) were genotyped and their fluconazole susceptibility was defined. A low rate of C. parapsilosisBSIs was correlated with high rates of consumption of fluconazole. No emergence of Candidaspecies with primary resistance to fluconazole was detected. However, genotyping with a complex DNA fingerprinting probe revealed that a single strain of C. parapsilosiswith decreasing susceptibility to fluconazole was responsible for cross-infections that caused BSIs in the NICU over a 12-year period. The emergence of fluconazole resistance in that strain was observed after more than 10 years of fluconazole prophylaxis. |
| Databáze: |
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