| Autor: |
Pires, Ivone L., Soares, Marcelo A., Speranza, Francisco A. B., Ishii, Solange K., Vieira, Maria C. G., Gouve^a, Maria I. F. S., es, de Oliveira, Fa´tima E., Magnanini, Monica M. F., Brindeiro, Rodrigo M., Tanuri, Amilcar |
| Zdroj: |
Journal of Clinical Microbiology; January 2004, Vol. 42 Issue: 1 p426-430, 5p |
| Abstrakt: |
ABSTRACTThe prevalence of mutations that confer resistance to antiretroviral drugs was examined in 56 drug-naive, human immunodeficiency virus type 1 (HIV-1)-infected individuals from the Army Health Service in Rio de Janeiro, Brazil. No primary protease inhibitor mutations were found, but secondary mutations were observed in 51.2% of the samples. Fourteen percent of the viruses had reverse transcriptase inhibitor-associated mutations. Comparative analysis of protease secondary mutations from four different time periods in drug-naive patients in the city of Rio de Janeiro has indicated constant rates for particular mutations. Changes in CD4 cell counts and HIV viral load over time in subtype B- and non-B-infected drug-naive patients were not significantly different. |
| Databáze: |
Supplemental Index |
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