Failure of Commercial Ligase Chain Reaction To Detect Mycobacterium tuberculosisDNA in Sputum Samples from a Patient with Smear-Positive Pulmonary Tuberculosis Due to a Deletion of the Target Region

Autor: Gilpin, Christopher M., Dawson, David J., O'Kane, Gabrielle, Armstrong, John G., Coulter, Christopher
Zdroj: Journal of Clinical Microbiology; June 2002, Vol. 40 Issue: 6 p2305-2307, 3p
Abstrakt: ABSTRACTWe report on a strain of Mycobacterium tuberculosiswith a deletion in the protein antigen B gene overlapping the probe binding sites for the Abbott Diagnostics LCx M. tuberculosis(LCx-MTB) probe assay. A false-negative result with the LCx-MTB assay delayed a laboratory diagnosis of tuberculosis.
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