Sequence Typing Confirms that Campylobacter jejuniStrains Associated with Guillain-Barre´ and Miller-Fisher Syndromes Are of Diverse Genetic Lineage, Serotype, and Flagella Type

Autor: Dingle, K. E., Van Den Braak, N., Colles, F. M., Price, Lawrence J., Woodward, David L., Rodgers, Frank G., Endtz, H. P., Van Belkum, A., Maiden, M. C. J.
Zdroj: Journal of Clinical Microbiology; September 2001, Vol. 39 Issue: 9 p3346-3349, 4p
Abstrakt: ABSTRACTGuillain-Barre´ syndrome (GBS) and Miller-Fisher syndrome (MFS) are correlated with prior infection by Campylobacter jejuniin up to 40% of cases. Nucleotide sequence-based typing of 25 C. jejuniisolates associated with neuropathy permitted robust comparisons with equivalent data from approximately 800 C. jejuniisolates not associated with neuropathy. A total of 13 genetic lineages and 20 flaAshort variable region nucleotide sequences were present among the 25 isolates. A minority of isolates (4 of 25) had the flaAshort variable region nucleotide sequences that were previously proposed as a marker for GBS-associated isolates. These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS.
Databáze: Supplemental Index