| Autor: |
Manchester, Marianne, Smith, Kent A., Eto, Danelle S., Perkin, Hugh B., Torbett, Bruce E. |
| Zdroj: |
The Journal of Virology; July 2002, Vol. 76 Issue: 13 p6636-6642, 7p |
| Abstrakt: |
ABSTRACTThe major cause of mortality in measles is generalized suppression of cell-mediated immunity that persists following virus clearance and results in secondary infections. The mechanisms contributing to this long-term immunosuppression are not clear. Herein we present evidence that measles virus (MV) disrupts hematopoiesis by infecting human CD34+cells and human bone marrow stroma. MV infection does not affect the hematopoietic capability of hematopoietic stem cells (HSCs) directly; rather, the infection impairs the ability of stroma to support development of HSCs. These results suggest that MV-mediated defects in hematopoiesis contribute to the long-term immunosuppression seen in measles. |
| Databáze: |
Supplemental Index |
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