| Autor: |
Cromwell, Mandy A., Veazey, Ronald S., Altman, John D., Mansfield, Keith G., Glickman, Rhona, Allen, Todd M., Watkins, David I., Lackner, Andrew A., Johnson, R. Paul |
| Zdroj: |
The Journal of Virology; September 2000, Vol. 74 Issue: 18 p8762-8766, 5p |
| Abstrakt: |
ABSTRACTInduction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8+lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor a4ß7 and traffic to the intestinal mucosa. SIV-specific CD8+T cells expressing a4ß7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express a4ß7. These results demonstrate the selective induction of SIV-specific CD8+T lymphocytes expressing a4ß7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine. |
| Databáze: |
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