| Autor: |
Schultz, Emily R., Rankin, George W., Blanc, Marie-Pierre, Raden, Brian W., Tsai, Che-Chung, Rose, Timothy M. |
| Zdroj: |
The Journal of Virology; May 2000, Vol. 74 Issue: 10 p4919-4928, 10p |
| Abstrakt: |
We have cloned and characterized the entire DNA polymerase gene and flanking regions from Kaposi's sarcoma-associated herpesvirus (KSHV) and two closely related macaque homologs of KSHV, retroperitoneal fibromatosis-associated herpesvirus-Macaca nemestrina(RFHVMn) and -Macaca mulatta(RFHVMm). We have also identified and partially characterized the corresponding genomic region of another KSHV-like herpesvirus, provisionally named “M. nemestrinarhadinovirus type 2 (MneRV-2),” with close similarity to rhesus rhadinovirus (RRV). A sequence comparison of these four macaque viruses and two KSHV-like gammaherpesviruses recently identified in African green monkeys, Chlorocebus rhadinovirus types 1 and 2 (ChRV-1 and ChRV-2) reveals the presence of two distinct lineages of KSHV-like rhadinoviruses in Old World primates. The first rhadinovirus lineage consists of KSHV and its closely related homologs RFHVMn, RFHVMm, and ChRV-1, while the second more distantly related lineage consists of RRV, MneRV-2, and ChRV-2. Our findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage. |
| Databáze: |
Supplemental Index |
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