| Autor: |
Lee, Bong Joo, Santee, Sybil, Von Gesjen, Sigrid, Ware, Carl F., Sarawar, Sally R. |
| Zdroj: |
The Journal of Virology; March 2000, Vol. 74 Issue: 6 p2786-2792, 7p |
| Abstrakt: |
ABSTRACTRespiratory challenge with murine gammaherpesvirus 68 (MHV-68) leads to an acute productive infection of the lung and a persistent latent infection in B lymphocytes, epithelia, and macrophages. The virus also induces splenomegaly and an increase in the number of activated CD8 T cells in the circulation. Lymphotoxin- a-deficient (LTa-/-) mice have no lymph nodes and have disrupted splenic architecture. Surprisingly, in spite of the severe defect in secondary lymphoid tissue, LTa-/-mice could clear a productive MHV-68 infection, although with delayed kinetics compared to wild-type mice, and could control latent infection. Cytotoxic T-cell activity was comparable in the lungs and spleens of LTa-/-and wild-type mice. However, splenic gamma interferon responses were substantially reduced in LTa-/-mice. Furthermore, LTa-/-mice failed to develop splenomegaly or lymphocytosis. Although germinal centers were absent, LTa-/-mice were able to class switch and showed significant virus-specific antibody titers. This work demonstrates that organized secondary lymphoid tissue is not an absolute requirement for the generation of immune responses to viral infections. |
| Databáze: |
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