Novel Role for E4 Region Genes in Protection of Adenovirus Vectors from Lysis by Cytotoxic T Lymphocytes

Autor: Kaplan, Johanne M., Armentano, Donna, Scaria, Abraham, Woodworth, Lisa A., Pennington, Sarah E., Wadsworth, Samuel C., Smith, Alan E., Gregory, Richard J.
Zdroj: The Journal of Virology; May 1999, Vol. 73 Issue: 5 p4489-4492, 4p
Abstrakt: ABSTRACTTarget cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.
Databáze: Supplemental Index