| Autor: |
Lewis, Ann J., Whitton, J. Lindsay, Hatalski, Carolyn G., Weissenbo¨ck, Herbert, Lipkin, W. Ian |
| Zdroj: |
The Journal of Virology; March 1999, Vol. 73 Issue: 3 p2541-2546, 6p |
| Abstrakt: |
ABSTRACTBorna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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