| Autor: |
Matteucci, D, Pistello, M, Mazzetti, P, Giannecchini, S, Del Mauro, D, Lonetti, I, Zaccaro, L, Pollera, C, Specter, S, Bendinelli, M |
| Zdroj: |
The Journal of Virology; November 1997, Vol. 71 Issue: 11 p8368-8376, 9p |
| Abstrakt: |
Cats immunized with cells infected with a primary isolate of feline immunodeficiency virus (FIV) and fixed with paraformaldehyde were challenged with cell-free or cell-associated homologous virus obtained ex vivo. Complete protection was observed in animals challenged with cell-free virus 4 months after completion of vaccination (p.v.) or with cell-associated virus 12 months p.v. In contrast, no protection was observed in cats challenged with cell-free virus 12 or 28 months p.v. or with cell-associated virus 37.5 months p.v. Prior to the 28- and 37.5-month challenges, the animals had received a booster dose of vaccine that had elicited a robust anamnestic immune response. These results show that vaccine-induced protection against ex vivo FIV is achievable but is relatively short-lived and can be difficult to boost. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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