Mapping and characterization of the origin of DNA replication of porcine circovirus

Autor: Mankertz, A, Persson, F, Mankertz, J, Blaess, G, Buhk, H J
Zdroj: The Journal of Virology; March 1997, Vol. 71 Issue: 3 p2562-2566, 5p
Abstrakt: The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins.
Databáze: Supplemental Index