Rescue of vaccinia virus lacking the E3L gene by mutants of E3L

Autor: Chang, H W, Uribe, L H, Jacobs, B L
Zdroj: The Journal of Virology; October 1995, Vol. 69 Issue: 10 p6605-6608, 4p
Abstrakt: Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to complement deletion of E3L correlates with the ability of mutated proteins to bind double-stranded RNA but not with their ability to migrate to the nucleus.
Databáze: Supplemental Index