Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals

Autor: Lineberger, D W, Kessler, J A, Waterbury, J A, Byrnes, V W, Massari, F, Staszewski, S, Emini, E A
Zdroj: The Journal of Virology; April 1995, Vol. 69 Issue: 4 p2637-2639, 3p
Abstrakt: A quantitative assessment of human immunodeficiency virus type 1 turnover in patient cell-free virion and infected-cell compartments under the dynamic conditions imposed by an effective antiviral therapy was performed. The turnover was rapid, and following a temporal lag, the extent of viral population replacement was eventually similar in both compartments. Each compartment therefore reflects considerable active virus replication.
Databáze: Supplemental Index