| Autor: |
Dewhurst, S, Dollard, S C, Pellett, P E, Dambaugh, T R |
| Zdroj: |
The Journal of Virology; December 1993, Vol. 67 Issue: 12 p7680-7683, 4p |
| Abstrakt: |
DNA sequences which have structural features suggestive of their functioning as an origin of lytic-phase DNA replication were previously identified in both human herpesvirus 6B strain Z29 [HHV-6B (Z29)] and in HHV-6A (U1102). Plasmid constructs containing the putative HHV-6B (Z29) oriLyt element were replicated after transfection into permissive T cells, when trans-acting factors were provided by HHV-6B (R-1) infection. By using this assay, the HHV-6B (Z29) oriLyt was mapped to a minimal region of approximately 400 bp which lies upstream of the gene that is homologous to herpes simplex virus UL29, a region that carries an origin in other betaherpesviruses and in some alphaherpesviruses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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