DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation

Autor: Ibanez, C E, Garcia, A, Stober-Grässer, U, Lipsick, J S
Zdroj: The Journal of Virology; November 1988, Vol. 62 Issue: 11 p4398-4402, 5p
Abstrakt: The product of the v-myb oncogene of avian myeloblastosis virus is a nuclear protein with an associated DNA-binding activity. We demonstrated that the highly conserved amino-terminal domain of p48v-myb is required for its associated DNA-binding activity. This activity is not required for the nuclear localization of p48v-myb. Furthermore, the associated DNA-binding activity and nuclear localization of p48v-myb together are not sufficient for transformation.
Databáze: Supplemental Index