Role of calcium in gamma interferon induction: inhibition by calcium entry blockers

Autor: Dianzani, F, Capobianchi, M R, Facchini, J
Zdroj: The Journal of Virology; June 1984, Vol. 50 Issue: 3 p964-965, 2p
Abstrakt: Mitogen-induced gamma interferon production by human lymphoid cell cultures was studied in the presence of calcium entry blockers. A dose-dependent inhibition was found in the presence of drug concentrations down to 10(-5) M. This finding shows that calcium flow through lymphocyte membranes after oxidation of membrane-bound galactose residues is also critical for triggering interferon production.
Databáze: Supplemental Index