| Autor: |
McHugh, Emma, Carmo, Olivia M. S., Blanch, Adam, Looker, Oliver, Liu, Boyin, Tiash, Snigdha, Andrew, Dean, Batinovic, Steven, Low, Andy J. Y., Cho, Hyun-Jung, McMillan, Paul, Tilley, Leann, Dixon, Matthew W. A. |
| Zdroj: |
mBio; April 2020, Vol. 11 Issue: 2 |
| Abstrakt: |
The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite-infected RBCs are central to severe adhesion-related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC membrane by defining the protein-protein interaction networks that function at the Maurer’s clefts controlling PfEMP1 loading and unloading. We characterize a protein needed for virulence protein trafficking and provide new insights into the mechanisms for host cell remodeling, parasite survival within the host, and virulence. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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