| Autor: |
Herkt, Christina E., Caffrey, Brian E., Surmann, Kristin, Blankenburg, Sascha, Gesell Salazar, Manuela, Jung, Anna L., Herbel, Stefanie M., Hoffmann, Kerstin, Schulte, Leon N., Chen, Wei, Sittka-Stark, Alexandra, Völker, Uwe, Vingron, Martin, Marsico, Annalisa, Bertrams, Wilhelm, Schmeck, Bernd |
| Zdroj: |
mBio; April 2020, Vol. 11 Issue: 2 |
| Abstrakt: |
Cases of Legionella pneumophilapneumonia occur worldwide, with potentially fatal outcome. When causing human disease, Legionellainjects a plethora of virulence factors to reprogram macrophages to circumvent immune defense and create a replication niche. By analyzing Legionella-induced changes in miRNA expression and genomewide chromatin modifications in primary human macrophages, we identified a cell-autonomous immune network restricting Legionellagrowth. This network comprises three miRNAs governing expression of the cytosolic RNA receptor DDX58/RIG-I, the tumor suppressor TP53, the antibacterial effector LGALS8, and MX1, which has been described as an antiviral factor. Our findings for the first time link TP53, LGALS8, DDX58, and MX1 in one miRNA-regulated network and integrate them into a functional node in the defense against L. pneumophila. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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