| Autor: |
Lin, Ti-Yu, Gross, William S., Auer, George K., Weibel, Douglas B. |
| Zdroj: |
mBio; January 2019, Vol. 10 Issue: 1 |
| Abstrakt: |
The phospholipid composition of the cell membrane influences the spatial and temporal biochemistry of cells. We studied molecular mechanisms connecting membrane composition to cell morphology in the model bacterium Rhodobacter sphaeroides. The peptidoglycan (PG) layer of the cell wall is a dominant component of cell mechanical properties; consequently, it has been an important antibiotic target. We found that the anionic phospholipid cardiolipin (CL) plays a role in determination of the shape of R. sphaeroidescells by affecting PG precursor biosynthesis. Removing CL in R. sphaeroidesalters cell morphology and increases its sensitivity to antibiotics targeting proteins synthesizing PG. These studies provide a connection to spatial biochemical control in mitochondria, which contain an inner membrane with topological features in common with R. sphaeroides. |
| Databáze: |
Supplemental Index |
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