In silicoexploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection

Autor: Divya, V.C., Saravanakarthikeyan, Balasubramanian
Zdroj: Journal of Oral Biosciences; December 2021, Vol. 63 Issue: 4 p416-419, 4p
Abstrakt: Salivary glands are considered important targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent evidence suggests that along with angiotensin converting enzyme 2, certain cell surface sialic acids (Sia) may function as receptors for binding SARS-CoV-2 spike protein. Over 50 forms of Sia have been identified in nature, with N-acetylneuraminic acid (Neu5Ac) being the most abundant. We explored the Human Protein Atlas repository to analyze important enzymes in Neu5Ac biosynthesis and propose a hypothesis that further highlights the significance of salivary glands in coronavirus disease 19 (COVID-19). This work may facilitate research into targeted drug therapies for COVID-19.
Databáze: Supplemental Index
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