DRD2and BDNFpolymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery

Autor: Nonino, Carla Barbosa, Barato, Mariana, Ferreira, Flávia Campos, Delfino, Heitor Bernardes Pereira, Noronha, Natalia Yumi, Nicoletti, Carolina Ferreira, Junior, Wilson Salgado, Welendorf, Caroline Rossi, Souza, Doroteia Rossi Silva, Ferreira-Julio, Maysa Araújo, Watanabe, Ligia Moriguchi, de Souza Pinhel, Marcela Augusta
Zdroj: Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity; 20210101, Issue: Preprints p1-8, 8p
Abstrakt: Aim: The aim of this study was to analyze the association and susceptibility of Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNFgenes with BED in patients with weight regain in the postoperative period of bariatric surgery. Methods: One hundred and seventy-seven individuals who underwent bariatric surgery with weight regain were evaluated and divided into two groups according to the BED diagnostic. The individuals were submitted to an anthropometric evaluation, analysis of the presence of BED using a validated questionnaire, and blood collection for genotyping of the polymorphisms rs6265 (BDNF) and rs1800497 (DRD2) by real-time polymerase chain reaction (RT-PCR). Results: The presence of wild-type alleles for rs1800497 (CC) and rs6265 (GG) was more frequent in patients without BED. Nevertheless, the presence of one or two variant alleles for rs1800497 (CT + TT) and rs6265 (GA + AA) was more frequent in patients with BED. The combination of the two studied SNPs prevailed in patients with BED. Conclusions: The presence of allele frequency of rs1800497 SNP in the DRD2gene and rs6265 SNP in the BDNFgene, isolated and/or combined, indicated an additional risk for the development of BED in patients with obesity, especially in the context of weight regain. Level of evidence: III (evidence obtained from the case–control analytic study).
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