PARP1, BRCA1 and androgen receptor expression in triple-negative breast cancer patients treated with neoadjuvant chemotherapy

Autor: Rashed, Hayam E., Monged, Randa E., Nawar, Nashwa, Alattar, Ahmed Z., Alnagar, Ahmed A., Abdelhamid, Mohamed I., Abdelaziz, Osama, Said, Nelly M.
Zdroj: Revista de Senología y Patología Mamaria; October-December 2022, Vol. 35 Issue: 4 p228-235, 8p
Abstrakt: Triple-negative breast cancer (TNBC) is an aggressive subtype, where no effective therapies have been established for it. Searching for therapeutic targets for TNBC patients is the aim of the current research. Poly adenosine diphosphate ribose polymerase (PARP1) inhibitors are promising antitumor therapy that have a high potency in BRCA1-deficient breast cancers.
Databáze: Supplemental Index