| Autor: |
Korch, Katerina M., Watson, Donald A. |
| Zdroj: |
Organic Letters; 20210101, Issue: Preprints |
| Abstrakt: |
The first total synthesis of the natural product impatien A is described. This concise synthesis features an aza-Heck cyclization to construct the complex spirocyclic ring system and provides a rare example of the use of aza-Heck cyclizations in complex molecule synthesis. To enable this key cyclization of an electrophilic nitrogen atom with a tetrasubstituted alkene, we utilized high-throughput experimentation to identify a new ligand and ultimately deliver impatien A in seven steps from known compounds. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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