| Abstrakt: |
Seven new steroidal alkaloids, 2-hydroxysalignarine-E (=(2'E,20S)-20-(dimethylamino)-2β-hydroxy-3β-(tigloylamino)pregn-4-ene; 1), 5,6-dihydrosarconidine (=(20S)-20-(dimethylamino)-3β-(methylamino)-5α-pregn-16-ene; 2), salignamine (=(20S)-20-(methylamino)-3β-methoxypregna-5,16-diene; 3), 2-hydroxysalignamine (=(20S)-20-(dimethylamino)-2β-hydroxy-3β-methoxypregna-5,16-diene; 4), salignarine-F (=(2'E, 20S)-20-(dimethylamino)-4β-hydroxy-3β-(tigloylamino)pregn-5-ene; 5), salonine-C (=(2'E,20S)-20-(dimethylamino)-3β-(tigloylamino)pregna-4,14-diene; 6), and N-[formyl(methyl)amino]salonine-B (=(20S)-20-[formyl(methyl)amino]-3β-methoxypregna-5,16-diene; 7) have been isolated from the MeOH extract of Sarcococca saligna, along with the six known alkaloids dictyophlebine (8), epipachysamine-D (9), saracosine (10), iso-N-formylchonemorphine (11), sarcodinine (12), and alkaloid-C (13). The structures of 17 were deduced from spectral data. Compounds 113 demonstrated significant activity against acetyl- and butyrylcholinesterase. |
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