| Autor: |
Clark, Simon, Cross, Martin L., Nadian, Allan, Vipond, Julia, Court, Pinar, Williams, Ann, Hewinson, R. Glyn, Aldwell, Frank E., Chambers, Mark A. |
| Zdroj: |
Infection and Immunity; August 2008, Vol. 76 Issue: 8 p3771-3776, 6p |
| Abstrakt: |
ABSTRACTIncreased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovisis a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovisinfections of cattle in the United Kingdom, and its vaccination against TB with M. bovisbacillus Calmette-Guérin (BCG) is an attractive disease control option. Delivery of BCG in oral bait holds the best prospect for vaccinating badgers over a wide geographical area. Using a guinea pig pulmonary challenge model, we evaluated the protective efficacy of candidate badger oral vaccines, based on broth-grown or ball-milled BCG, delivered either as aqueous suspensions or formulated in two lipids with differing fatty acid profiles (one being animal derived and the other being vegetable derived). Protection was determined in terms of increasing body weight after aerosol challenge with virulent M. bovis, reduced dissemination of M. bovisto the spleen, and, in the case of one oral formulation, restricted growth of M. bovisin the lungs. Only oral BCG formulated in lipid gave significant protection. These data point to the potential of the BCG-lipid formulation for further development as a tool for controlling tuberculosis in badgers. |
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