| Autor: |
Xu, Wenhao, Liang, Mingli, Su, Wenjing, Yang, Jinli, Pu, Faxiang, Xie, Zhangfu, Jin, Kongliang, Polyakov, Nikolay E., Dushkin, Alexander V., Su, Weike |
| Zdroj: |
Journal of Drug Delivery Science and Technology; December 2021, Vol. 66 Issue: 1 |
| Abstrakt: |
This study aimed to overcome the current challenges of active oil encapsulation, such as the complex preparation process, low encapsulation efficiency, and poor water solubility. Using mechanochemical method prepared celery seed oil/methyl-β-cyclodextrin nanocapsule (CsNIs). The entrapment efficiency was determined by UV–vis spectrophotometry, and characterized by DLS, FT-IR, XRD, SEM and TEM. A mouse model of hyperuricemia induced by potassium oxate (PO) was used to investigate the antihyperuricemia and nephroprotective effects of the CsNIs. CsNIs formed by hydrogen bonding of Celery Seed Oil (CsO) with MeβCD had high encapsulation efficiency (98.39%), and had more stable antioxidant activity under sunlight exposure. The water solubility was improved by 30-fold. CsNIs will self-assemble into nano-spheres in aqueous solution and be slowly released to 77.2% in 48 h. Uric acid levels and the degree of renal injury were significantly lower in hyperuricemia (HUA) mice. In this study, the water solubility and stability of celery seed oil were improved. And it provides a green, simple, and efficient encapsulation strategy for the encapsulation of active oils. |
| Databáze: |
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