| Autor: |
Rogers, James, Hakki, Amal, Perkins, Izabella, Newton, Catherine, Widen, Ray, Burdash, Nicholas, Klein, Thomas, Friedman, Herman |
| Zdroj: |
Infection and Immunity; June 2007, Vol. 75 Issue: 6 p3205-3208, 4p |
| Abstrakt: |
ABSTRACTDendritic cells (DCs) have a critical role in linking innate to adaptive immunity, and this transition is regulated by the up-regulation of costimulatory and major histocompatibility complex (MHC) molecules as well as Toll-like receptors. These changes in DCs have been observed to occur following microbial infection, and in the present study, we examined the effect of Legionella pneumophilainfection on the expression of these DC markers. We showed that bone marrow-derived DC cultures from BALB/c mice infected with live L. pneumophilaresulted in the up-regulation of Toll-like receptors 2 and 4 and the activation of CD40, CD86, and MHC class I/II molecules. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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