| Autor: |
Pimenta, F. C., Miyaji, E. N., Arêas, A. P. M., Oliveira, M. L. S., de Andrade, A. L. S. S., Ho, P. L., Hollingshead, S. K., Leite, L. C. C. |
| Zdroj: |
Infection and Immunity; August 2006, Vol. 74 Issue: 8 p4939-4944, 6p |
| Abstrakt: |
ABSTRACTOne of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniaeis PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with elevated sequence identity in other viridans group streptococci. In this work, we demonstrate that intranasal immunization with a cholera toxin B subunit-PsaA fusion protein is able to protect mice against colonization with S. pneumoniaebut does not significantly alter the natural oral or nasopharyngeal microbiota of mice. |
| Databáze: |
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