| Autor: |
Roberts, Frank A., Houston, Laura S., Lukehart, Sheila A., Mancl, Lloyd A., Persson, G. Rutger, Page, Roy C. |
| Zdroj: |
Infection and Immunity; February 2004, Vol. 72 Issue: 2 p1166-1168, 3p |
| Abstrakt: |
ABSTRACTInterleukin-1β, tumor necrosis factor alpha, prostaglandin E2(PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalisvaccine followed by ligature-induced periodontitis. Only PGE2levels were dramatically suppressed (P< 0.0001) in immunized animals versus controls. A significant correlation (P< 0.027) was also found between PGE2levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2in periodontal destruction. |
| Databáze: |
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