| Autor: |
Guiney, Donald G., Hasegawa, Patty, Cole, Sheri P. |
| Zdroj: |
Infection and Immunity; July 2003, Vol. 71 Issue: 7 p4163-4166, 4p |
| Abstrakt: |
ABSTRACTDendritic cells are potent antigen-presenting cells that are present in the gastrointestinal tract and are required for the induction of a Th1 T-cell acquired immune response. Since infection with the gastric pathogen Helicobacter pylorielicits a Th1 cell response, the interaction of these organisms with dendritic cells should reflect the Th1 bias. We incubated H. pyloriwith cultured human dendritic cells and measured the cytokine induction profile, comparing the response to that induced by Salmonella entericaserovar Typhimurium. We found that H. pyloriinduced little interleukin 6 (IL-6) and essentially no IL-10 in contrast to S. enterica.However, H. pyloriinduced levels of IL-12 that were 30% of those induced by S. enterica,indicating a Th1 response. An isogenic cagEmutant of H. pylorilost about 50% of its IL-12-inducing ability, suggesting a role for the cagtype IV secretion system in the stimulation of dendritic cells. |
| Databáze: |
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