| Autor: |
Smith, Steven M., Klein, Michèl R., Malin, Adam S., Sillah, Jackson, Huygen, Kris, Andersen, Peter, McAdam, Keith P. W. J., Dockrell, Hazel M. |
| Zdroj: |
Infection and Immunity; December 2000, Vol. 68 Issue: 12 p7144-7148, 5p |
| Abstrakt: |
ABSTRACTIntracellular flow cytometry analysis of perforin production by CD8+T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8+T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients. |
| Databáze: |
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