| Autor: |
Okenu, Daniel M. N., Riley, Eleanor M., Bickle, Quentin D., Agomo, Philip U., Barbosa, Arnoldo, Daugherty, Jon R., Lanar, David E., Conway, David J. |
| Zdroj: |
Infection and Immunity; October 2000, Vol. 68 Issue: 10 p5559-5566, 8p |
| Abstrakt: |
ABSTRACTInvasion of human erythrocytes by Plasmodium falciparummerozoites is a multistep process. For many strains of the parasite, part of this process requires that the erythrocyte binding antigen 175 (EBA-175) of the merozoite binds to sialic acid residues of glycophorin A on the erythrocyte surface, a receptor-ligand interaction which represents a potential target for inhibition by antibodies. This study characterizes the reactivity of naturally acquired human antibodies with four recombinant proteins representing parts of EBA-175 (region II, regions III to V, and the dimorphic C and F segment region) in populations in which the organism is endemic. Serum immunoglobulin G (IgG) recognizing the recombinant proteins is predominantly of the IgG1 and IgG3 subclasses, and its prevalence increases with age. In a large population study in The Gambia, serum positivity for IgG or IgG1 and IgG3 subclass antibodies to each of the EBA-175 recombinant antigens was not significantly associated with subsequent protection from clinical malaria. However, there was a trend indicating that individuals with high levels of IgG to region II may have some protection. |
| Databáze: |
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