| Autor: |
Bodetti, Tracey J., Timms, Peter |
| Zdroj: |
Infection and Immunity; May 2000, Vol. 68 Issue: 5 p2744-2747, 4p |
| Abstrakt: |
ABSTRACTChlamydia pneumoniaeis a common respiratory pathogen of humans which, in addition to causing disease at the respiratory site, has recently been linked to disease at other body sites. IfC. pneumoniaedoes contribute to disease at nonrespiratory sites, then it must have a mechanism by which it reaches these sites. We analyzed the peripheral blood mononuclear cell (PBMC) fractions from 60 healthy human blood donors for the presence of C. pneumoniaeDNA (by ompAPCR) and chlamydial antigens (by genus- and species-specific monoclonal antibody staining). Ten of the sixty (16.7%) blood donors were C. pneumoniaepositive by PCR, and all 10 of these PCR-positive individuals' samples demonstrated specific staining with anti-C. pneumoniaemonoclonal antibodies. The only other host naturally infected withC. pneumoniaeis the koala, in which the bacterium also causes respiratory infections. We demonstrated the presence of C. pneumoniaeDNA and antigens in the PBMC fractions of 30% of 20 koalas tested. Our finding of C. pneumoniae-infected PBMCs in koalas as well as humans suggests that the ability to infect PBMCs and to disseminate from the respiratory site is not restricted to the human biovar of C. pneumoniaebut is a general characteristic of this chlamydial species. |
| Databáze: |
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