| Autor: |
Ekman, Päivi, Saarinen, Marja, He, Qiushui, Virtala, Mika, Salmi, Marko, Granfors, Kaisa |
| Zdroj: |
Infection and Immunity; July 1999, Vol. 67 Issue: 7 p3670-3673, 4p |
| Abstrakt: |
ABSTRACTNitric oxide (NO) has a central role in host defense against intracellular microbes. HLA-B27 has been shown to directly modulate host-microbe interaction in vitro, leading to the impaired elimination of Salmonellain human monocytic U937 cells. Here, we studied whether impaired elimination of Salmonellawould result from differences in NO production between HLA-B27- and HLA-A2-transfected U937 cells. Both human monocytic transfectants produced NO equally well and killed Salmonellavia NO-independent mechanisms. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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