| Autor: |
Bradshaw, David J., Marsh, Philip D., Watson, G. Keith, Allison, Clive |
| Zdroj: |
Infection and Immunity; October 1998, Vol. 66 Issue: 10 p4729-4732, 4p |
| Abstrakt: |
ABSTRACTCoaggregation is a well-characterized phenomenon by which specific pairs of oral bacteria interact physically. The aim of this study was to examine the patterns of coaggregation between obligately anaerobic and oxygen-tolerant species that coexist in a model oral microbial community. Obligate anaerobes other than Fusobacterium nucleatumcoaggregated only poorly with oxygen-tolerant species. In contrast, F. nucleatumwas able to coaggregate not only with both oxygen-tolerant and other obligately anaerobic species but also with otherwise-noncoaggregating obligate anaerobe–oxygen-tolerant species pairs. The effects of the presence or absence of F. nucleatumon anaerobe survival in both the biofilm and planktonic phases of a complex community of oral bacteria grown in an aerated (gas phase, 200 ml of 5% CO2in air · min−1) chemostat system were then investigated. In the presence of F. nucleatum, anaerobes persisted in high numbers (>107· ml−1in the planktonic phase and >107· cm−2in 4-day biofilms). In an equivalent culture in the absence of F. nucleatum, the numbers of black-pigmented anaerobes (Porphyromonas gingivalisand Prevotella nigrescens) were significantly reduced (P≤ 0.001) in both the planktonic phase and in 4-day biofilms, while the numbers of facultatively anaerobic bacteria increased in these communities. Coaggregation-mediated interactions between F. nucleatumand other species facilitated the survival of obligate anaerobes in aerated environments. |
| Databáze: |
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