| Autor: |
Letscher-Bru, Valerie, Villard, Odile, Risse, Bernhard, Zauke, Michael, Klein, Jean-Paul, Kien, Truong T. |
| Zdroj: |
Infection and Immunity; September 1998, Vol. 66 Issue: 9 p4503-4506, 4p |
| Abstrakt: |
ABSTRACTWe studied the immune response induced in mice by recombinantToxoplasma gondiisurface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%. |
| Databáze: |
Supplemental Index |
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