Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

Autor: Sadick, M D, Street, N, Mosmann, T R, Locksley, R M
Zdroj: Infection and Immunity; December 1991, Vol. 59 Issue: 12 p4710-4714, 5p
Abstrakt: Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.
Databáze: Supplemental Index