| Autor: |
Thomas, W R, Callow, M G, Dilworth, R J, Audesho, A A |
| Zdroj: |
Infection and Immunity; June 1990, Vol. 58 Issue: 6 p1909-1913, 5p |
| Abstrakt: |
An Escherichia coli clone producing a high-molecular-weight surface antigen of Haemophilus influenzae type b (Hib) was isolated from a library of Hib DNA fragments cloned as lysogens in a lambda replacement vector. The antigen is found in sarcosyl-insoluble outer membrane protein preparations and was produced by all 36 H. influenzae isolates tested. Absorption studies indicated that the antigen is a surface determinant on all isolates tested. Antibodies to the antigen (D15) were found in eight of nine convalescent-phase sera from children with invasive Hib infection. Affinity-purified antibodies prepared against the cloned antigen gave protection against the development of bacteremia in a rat pup model. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
