Effect of viral and bacterial pneumonias on cell-mediated immunity in humans

Autor: Kauffman, C A, Linnemann, C C, Schiff, G M, Phair, J P
Zdroj: Infection and Immunity; January 1976, Vol. 13 Issue: 1 p78-83, 6p
Abstrakt: Cell-mediated immunity (CMI) was assessed during infection and after convalescence in 12 patients with influenza pneumonia and 10 patients with bacterial pneumonia. The patients with influenza pneumonia had a marked impairment of skin test reactivity, and their lymphocytes showed a diminished response to phytohemagglutinin and streptokinase-streptodornase stimulation in vitro. Suppression of CMI was related to the severity of the pneumonia. Patients with bacterial pneumonia showed as great a suppression of the response to phytohemagglutinin and streptokinase-streptodornase as the patients with viral pneumonia. All parameters of CMI returned to normal in both groups after convalescence. The depression of CMI could not be related to a decrease in the number of thymus-derived lymphocytes or to serum-suppressive factors in these patients.
Databáze: Supplemental Index