| Autor: |
Olson, Gerald A., Guggenheim, Bernard, Small, Parker A. |
| Zdroj: |
Infection and Immunity; February 1974, Vol. 9 Issue: 2 p273-278, 6p |
| Abstrakt: |
Immune sera to strains of Streptococcus mutanswere found to inhibit agglutination of bacterial suspensions to which either high-molecular-weight dextran or sucrose was added. This inhibitory activity was shown to be mediated by antibody of the immunoglobulin G class. A semiquantitative assay was developed which demonstrated cross-inhibition of dextran/sucrose-induced agglutination among several strains of S. mutans. Antiserum to a partially purified glucosyltransferase was found to lack agglutination inhibition activity, consistent with the hypothesis that the dextran-binding antigen detected by the assay is immunologically distinct from the glucan-synthetic enzyme. A model for glucan synthesis and binding consistent with the reported data is described. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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