| Autor: |
Jackson, Anne L., Walters, Curla S. |
| Zdroj: |
Infection and Immunity; October 1972, Vol. 6 Issue: 4 p545-549, 5p |
| Abstrakt: |
CD-1 mice immunized with sheep red blood cells (SRBC) or Escherichia colilipopolysaccharide (LPS), developed splenic plaque-forming cells (PFC) producing low-molecular-weight antibody; these cells were detected by means of purified rabbit antisera to mouse γ1, γ2a, and γ2bimmunoglobulins. In contrast to SRBC, the primary γ1response to LPS was absent and γ2aand γ2bPFC were detected irregularly. Both immunogens elicited a secondary cellular response in all three subclasses without a corresponding increase in “direct” or γMPFC. An increase in serum bactericidal antibody following a second injection of LPS was not parallelled by an increase in splenic γMPFC; it might therefore involve the synthesis of γ2complement-fixing antibody. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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