| Autor: |
Roman, François, Clément, Frédéric, Dewé, Walthère, Walravens, Karl, Maes, Cathy, Willekens, Julie, De Boever, Fien, Hanon, Emmanuel, Leroux-Roels, Geert |
| Zdroj: |
Clinical and Vaccine Immunology (formerly CDLI); March 2011, Vol. 18 Issue: 5 p835-843, 9p |
| Abstrakt: |
ABSTRACTThe influence of AS03A, a tocopherol oil-in-water emulsion-based adjuvant system, on humoral and cell-mediated responses to A/California/7/2009 H1N1 pandemic vaccine was investigated. In two observer-blind studies, a total of 261 healthy adults aged 18 to 60 years were randomized to receive either AS03A-adjuvanted H1N1 vaccine containing 3.75 µg hemagglutinin (HA) or nonadjuvanted H1N1 vaccine containing 15 or 3.75 µg HA on days 0 and 21. Hemagglutination inhibition (HI) antibody and T-cell responses were analyzed up to day 42. A first dose of AS03A-adjuvanted vaccine (3.75 µg HA) or nonadjuvanted vaccine (15 µg HA) induced HI responses of similar magnitudes that exceeded licensure criteria (e.g., 94 to 100% with titers of =40). A lower response following 3.75 µg HA without adjuvant was observed (73% with titers of =40). Following a second dose, geometric mean HI titers at day 42 were higher for AS03A-adjuvanted vaccine (636 and 637) relative to nonadjuvanted vaccine (341 for 15 µg HA and 150 for 3.75 µg HA). Over the 42-day period, the increase in frequency of A/H1N1/2009-specific CD4+T cells was significantly higher in the adjuvanted group than in the nonadjuvanted group. There was no evidence of correlation between baseline CD4+T-cell frequencies and day 21 HI antibody titers, while there was some correlation (R= 0.35) between day 21 CD4+T-cell frequencies and day 42 HI titers. AS03Aadjuvant enhanced the humoral and CD4+T-cell-mediated responses to A/H1N1/2009 vaccine. Baseline A/H1N1/2009-specific CD4+T-cell frequencies did not predict post-dose 1 antibody responses, but there was some correlation between post-dose 1 CD4+T-cell frequencies and post-dose 2 antibody responses. |
| Databáze: |
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