| Autor: |
Shao, Jun-Jun, Wong, Chung Kai, Lin, Tong, Lee, Shuk Kwan, Cong, Guo-Zheng, Sin, Fion Wai Yee, Du, Jun-Zheng, Gao, Shan-Dian, Liu, Xiang-Tao, Cai, Xue-Peng, Xie, Yong, Chang, Hui-Yun, Liu, Ji-Xing |
| Zdroj: |
Clinical and Vaccine Immunology (formerly CDLI); November 2010, Vol. 18 Issue: 1 p143-149, 7p |
| Abstrakt: |
ABSTRACTIn order to develop a completely safe immunogen to replace the traditional inactivated vaccine, a tandem-repeat multiple-epitope recombinant vaccine against foot-and-mouth disease (FMD) virus (FMDV) type O was developed. It contained three copies each of residues 141 to 160 and 200 to 213 of VP1 of the O/China/99 strain of FMDV coupled with a swine immunoglobulin G heavy-chain constant region (scIgG). The data showed that the multiple-epitope recombinant vaccine elicited high titers of anti-FMDV specific antibodies in swine at 30 days postvaccination (dpv) and conferred complete protection against a challenge with 10350% swine infective doses of the O/China/99 strain. The anti-FMDV specific antibody titers were not significantly different between the multiple-epitope recombinant vaccine and the traditional vaccine (ttest, P> 0.05). The number of 50% pig protective doses was 6.47, which is higher than the number recommended by the World Organization for Animal Health. The multiple-epitope recombinant vaccine resulted in a duration of immunity of at least 6 months. We speculate that the multiple-epitope recombinant vaccine is a promising vaccine that may replace the traditional inactivated vaccine for the prevention and control of FMD in swine in the future. |
| Databáze: |
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