| Autor: |
Nardelli, Dean T., Cloute, Joseph P., Luk, K. H. Kevin, Torrealba, Jose, Warner, Thomas F., Callister, Steven M., Schell, Ronald F. |
| Zdroj: |
Clinical and Vaccine Immunology (formerly CDLI); June 2005, Vol. 12 Issue: 6 p786-792, 7p |
| Abstrakt: |
ABSTRACTCD4+CD25+T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4+CD25+T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4+CD25+T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals. |
| Databáze: |
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